Tom Isenbarger

Registered United States Patent Attorney
Madison, Wisconsin

J.D., University of Wisconsin Law School
May 2010, magna cum laude (GPA 3.73/4.0, top 4%)
Articles Editor, Wisconsin Law Review
Order of the Coif

Ph.D., University of Wisconsin Department of Biomolecular Chemistry
May 2001 (GPA 4.0/4.0)

B.S., Biochemistry, University of Notre Dame
May 1994, summa cum laude (GPA 3.9/4.0, class rank 8/1785)

State Bar of Wisconsin
United States Patent and Trademark Office

Legal experience
Casimir Jones SC (Middleton, Wisconsin)
Shareholder, January 2018–present
Attorney, September 2010–December 2017

University of Wisconsin Law School Law & Entrepreneurship Clinic
Member, 2009–2010

Foley & Lardner LLP
Summer Associate, Intellectual Property, summers of 2008 & 2009

Scientific Research Experience
University of Wisconsin Departments of Bacteriology and Plant Pathology
Postdoctoral Scientist, 2004–2007
Research Advisor: Jo Handelsman
Culture-independent analysis of a hypersaline microbial mat community
Metagenomics of soil and insect gut microbial communities

Harvard Medical School Department of Genetics and
Massachusetts General Hospital Department of Molecular Biology
Postdoctoral Fellow, 2001–2004
Research Advisor: Gary Ruvkun
SETG: the Search for Extraterrestrial Genomes
Identification and analysis of small RNAs involved in stem cell-mediated regeneration

University of Wisconsin Department of Biomolecular Chemistry
Postdoctoral Scientist, 2001
Research Advisor: Robert H. Fillingame
Structural studies of E. coli F1F0 ATP synthase subunit a

University of Wisconsin Department of Biomolecular Chemistry
Doctoral Research, 1994–2001
Research Advisor: Mark P. Krebs
Thermodynamic stability of membrane protein oligomerization

Honors & Awards
ABA-BNA Award for Excellence In the Study of Intellectual Property Law
Wisconsin State Bar/UW Law School Academic Achievement Award for Constitutional Law
Finalist (top 5) for University of Wisconsin Law School best student brief competition
University of Wisconsin Law School Dean’s List (for all semesters eligible)
University of Wisconsin Law School Dean’s Academic Achievement Award
National Institutes of Health Ruth Kirschstein NRSA Postdoctoral Fellowship
National Institutes of Health Molecular Biophysics Graduate Training Grant
National Science Foundation Graduate Fellowship
University of Wisconsin Medical School Garvin Cremer Scholarship
Wisconsin Alumni Research Foundation Student Fellowship
University of Notre Dame Outstanding Biochemistry Student, Class of 1994
Indiana Basketball Hall of Fame Scholarship

Citations: 1364 (h-index 9; i10-index 9)

Isenbarger, T.A., In re Kubin’s Reinvigorated Nonobviousness Standard for DNA Patents, Wisconsin Law Review 2009(6): 1435–1470 (2010). SSRN:

Friedländer, M., Adamidi, C., Han, T., Lebedeva, S., Isenbarger, T., Hirst, M., Marra, M., Nusbaum, C., Lee, W., Jenkin, J., Sanchez Alvarado, A., Kim, J., Rajewsky, N. High-resolution Profiling and Discovery of Planarian Small RNAs, PNAS 106(28): 11546–11551 (2009).

Isenbarger, T.A., Carr, C.E., Johnson, S.S., Finney, M., Church, G.M., Gilbert, W., Zuber, M.T., & Ruvkun, G. The Most Conserved Genome Segments for Life Detection on Earth and Other Planets, Origins of Life and Evolution of Biospheres 38(6): 517–533 (2008).

Isenbarger, T.A., Finney, M., Handelsman, J., & Ruvkun, G. Miniprimer PCR, a New Lens for Viewing the Microbial World, Appl. Environ. Microbiol. 74(3): 745–752 (2008).

Isenbarger, T.A. The Bacteriorhodopsin Lattice as a Model for Quantifying Interactions that Stabilize Membrane Protein Complexes, Ph.D. dissertation (2001).

Isenbarger, T.A., & Krebs, M.P. Thermodynamic Stability of the Bacteriorhodopsin Lattice As Measured by Lipid Dilution. Biochemistry 40(39): 11923–11931 (2001).

Ng, W.V., Kennedy, S.P., . . ., Isenbarger, T.A., . . ., Hood, L., & DasSarma, S. Genome Sequence of Halobacterium species NRC-1. PNAS 97(22): 11677–12388 (2000).

Krebs, M.P., & Isenbarger, T.A. Structural Determinants of Purple Membrane Assembly. Biochim. Biophys. Acta 1460(1): 15–26 (2000).

Isenbarger, T.A., & Krebs, M.P. Role of Helix-Helix Interactions in Assembly of the Bacteriorhodopsin Lattice. Biochemistry 38(28): 9023–9030 (1999).

Research Presentations
Applied and Environmental Microbiology Gordon Conference, July 2005, New London, CT
“Accessing the Functional Diversity of Uncultured Soil Microorganisms by Metagenomics”

Japanese New Energy and Industrial Technology Development Organization (NEDO) Symposium on “The Collection of Genetic Resources of As Yet Uncultured Microorganisms”, November 2004, Tokyo, Japan
“Unculturable Bacteria in Microbial Communities from Soil and Insect Guts”

Department of Biomolecular Chemistry Seminar Series, April 2000, Madison, WI
“Bacteriorhodopsin As a Model for Quantifying the Interactions that Stabilize Membrane Protein Complexes”

Department of Biomolecular Chemistry Seminar Series, October 1998, Madison, WI
“Transmembrane Helix-Helix Interactions and Their Role in Bacteriorhodopsin Lattice Assembly”

FASEB Summer Research Conference: Molecular Biophysics of Cellular Membranes, July 2000, Saxton’s River, VT
“Bacteriorhodopsin as a Model for Quantifying the Interactions that Stabilize Membrane Protein Complexes” (Poster presentation)

Third European Symposium of the Protein Society, September 1999, Garmisch-Partenkirchen, Germany
“Helix-Helix Interactions in Assembly of the Bacteriorhodopsin Lattice” (Poster presentation)

Howard Hughes Medical Institute International Symposium: New Approaches to Membrane Protein Structure and Function, August 1998, Madison, WI
“Specific Packing Interactions Between Bacteriorhodopsin Monomers are Required for Purple Membrane Assembly” (Poster presentation)

Skills & Areas of Expertise
CRISPR technologies
Nucleic acid amplification
Nucleic acid and protein diagnostics
DNA sequencing
Molecular genetics and genotyping
Environmental microbiology
Medical imaging
Mechanical devices
Automated driving
Metagenomic library construction and screening
Natural products discovery with a focus on antibiotic discovery
Culture-independent identification and analysis of microbes
RNA interference
Spectroscopy (CD, UV/Vis)
X-ray diffraction
Membrane protein structure
Three-dimensional printing
Index-based insurance
Vector design and construction
Mastery of UNIX and X11 bioinformatics tools, perl, molecular modeling
Experience developing applications in OOP environments (REALBasic, Visual Basic, R)